The Brain was a brilliant scientist, and lackey to the military criminal, the General. The Brain assisted the General in his 'war against Superboy', helping to destroy all Superboy's robots, and then creating a duplicator ray to make a Bizarro-Krypto, who lured Superboy's pet, the real Krypto, off Earth, and left him to be killed by a creature that sucked out lifeforce.
The General tricked Superboy and left him exposed to kryptonite, but Superboy used his unaffected powers to join bits of his broken Superboy robots together to make a new one, which rescued him. Meanwhile, Bizarro-Krypto decided not to let Krypto die after all. Superboy then put an end to the criminal career of both the General and the Brain.
