When Commissioner Gordon and Perry White researched the past cases of Superman, Batman and Robin, they were infected by a gas from an overturned bottle in the Fortress of Solitude. The effects of the gas turned Gordon and Perry into evildoers. They rejuvenated themselves with a special serum, Perry charged his body with super-energy and then they opposed their former friends Superman and Batman as Anti-Superman and Anti-Batman.
The crooks gave the heroes a hard time until Batman deduced the truth of what happened and he told Superman to bring the antidote to the gas as soon as possible. Going to the criminal's secret hideout, Batman and Robin prevented them from using the gas to rejuvenate until Superman arrived with the antidote and cured their friends.